ABSTRACT
This study included 50 patients with pure bilharziasis and mixed liver cirrhosis at different clinical stages. They were selected from Inpatient Medical Department, Mansoura University Hospital. Ten healthy individuals were selected as a control group Leucine- and Methionine - enkephalins plasma levels were estimated in all the participants and after their classification into the following groups: group of intestinal billharziasis [10 patients], non - ascetic group [10 BHF patients + 12 patients with mixed cirrhosis] and ascetic group [8 BHF patients + 12 patients with mixed cirrhosis]. This study was shown that plasma enkephalins level is significantly increased in ascetic than in non- ascetic group of patients and this increase is proportional to the degree of derangement of hepatic function